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Selected References

  1. Neuer Antikörper greift nur Tumorzellen an, nicht die gesunden

    Ärzte Zeitung online, 29.12.2010
    Online Article

  2. Stangl et al:
    Targeting membrane heat-shock protein 70 (Hsp70)
    Proc Natl Acad Sci U S A. 2010 Dec 27
    Abstract + Full Text (pubmed)

  3. Stangl et al:
    In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody
    J Cell Mol Med. 2010 Apr 6.
    Abstract (pubmed)

  4. Elsner et al:
    The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.
    J Cell Mol Med. 2009 Feb 4
    Abstract (pubmed)

  5. Milani et al:
    Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report.
    J Transl Med. 2009 Jun 23;7:50
    Abstract + Full Text (pubmed)

  6. Gehrmann et al:
    Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3
    PLoS ONE. 2008 Apr 2;3(4):e1925
    Abstract + Full Text (pubmed)

  7. Gross et al:
    An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation
    Leuk Res. 2008 Apr;32(4):527-34. Epub 2007 May 31
    Abstract (pubmed)

  8. Multhoff:
    Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance
    Methods. 2007 Nov;43(3):229-37
    Abstract (pubmed)

  9. Sherman and Multhoff:
    Heat shock proteins in cancer
    Ann N Y Acad Sci. 2007 Oct;1113:192-201
    Abstract (pubmed)

  10. Pfister et al:
    Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis
    Cancer. 2007 Aug 15;110(4):926-35
    Abstract (pubmed)

  11. Schmitt et al:
    Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
    J Leukoc Biol. 2007 Jan;81(1):15-27. Epub 2006 Aug 24
    Abstract + Full Text (pubmed)

  12. Steiner et al:
    High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis
    Leukemia. 2006 Nov;20(11):2076-9. Epub 2006 Sep 21
    Abstract (pubmed)

  13. Stangl et al:
    Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells
    J Immunol. 2006 May 15;176(10):6270-6
    Abstract + Full Text (pubmed)

  14. Stangl et al:
    Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells.
    J Immunol. 176(10):6270-6, 2006.
    Abstract (pubmed)

  15. Radons and Multhoff:
    Immunostimulatory functions of membrane-bound and exported heat shock protein 70.
    Exerc Immunol Rev.; 11:17-33, 2005.
    Abstract + Full Text (pubmed)

  16. Gastpar et al:
    Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
    Cancer Res. 65(12):5238-47, 2005.
    Abstract (pubmed)

  17. Bausero et al:
    Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.
    J Immunol. 175(5):2900-12, 2005.
    Abstract (pubmed)

  18. Gehrmann et al:
    Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
    Cell Death Differ. 12(1):38-51, 2005.
    Abstract (pubmed)

  19. Nylandsted et al:
    Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
    J Exp Med. 200(4):425-35, 2004.
    Abstract (pubmed)

  20. Krause et al:
    Treatment of cancer patients with autologous ex vivo Hsp70 peptide activated NK cells: a clinical phase I trial.
    Clin Cancer Res. 10 (11):3699-707, 2004.
    Abstract (pubmed)

  21. Gehrmann et al:
    Differential up-regulation of cytosolic and membrane-bound Hsp70 in tumor cells by anti-inflammatory drugs.
    Clin Cancer Res. 10 (10):335464, 2004.
    Abstract (pubmed)

  22. Gastpar et al:
    The cell surface-localized Hsp70 epitope TKD induces migration and cytoltyic activity selectively in human NK cells.
    J Immunol 172:972-80, 2004.
    Abstract (pubmed)

  23. Kleinjung et al:
    Hsp70 membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
    Int J Radiat Oncol Biol Phys. 57(3):820-6, 2003.
    Abstract (pubmed)

  24. Gross et al:
    Cell surface-bound Hsp70 mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
    J Biol Chem. 17:41173-81, 2003.
    Abstract (pubmed)

  25. Gross et al:
    Hsp70-reactivity is associated with increased cell surface density of CD94 and CD56.
    Cell Stress & Chaperones. 8(4):348-60, 2003.
    Abstract (pubmed)

  26. Farkas et al:
    Hsp70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
    Melanoma Res. 13:147-52, 2003.
    Abstract (pubmed)

  27. Gehrmann et al:
    Membrane-bound Hsp70 in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells.
    Haematologica. 88:474-6, 2003.

  28. Gross et al:
    Interaction of Hsp70 peptide with NK cells involves the NK receptor CD94.
    Biol Chem. 384(2):267-79, 2003.
    Abstract (pubmed)

  29. Moser et al:
    Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by Hsp70-peptide-activated, CD94 positive natural killer cells.
    Cell Stress Chaperones. 7(4):365-73, 2002.
    Abstract (pubmed)

  30. Multhoff:
    Activation of natural killer cells by Hsp70.
    Int J Hyperthermia. 18:576-85, 2002.
    Abstract (pubmed)

  31. Multhoff et al:
    A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity.
    Cell Stress Chaperones. 6(4):337-44, 2001.
    Abstract (pubmed)

  32. Multhoff et al:
    Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.
    Int J Cancer. 88:791-7, 2000.
    Abstract (pubmed)

  33. Multhoff et al:
    Hsp70 stimulates proliferation and cytolytic activity of natural killer cells.
    Hematol. 27:1627-36, 1999.
    Abstract (pubmed)

  34. Multhoff et al:
    Hsp70 on tumor cells: a recognition structure for natural killer cells.
    J Immunol. 58:4341-50, 1997.
    Abstract (pubmed)