Selected References
- Neuer Antikörper greift nur Tumorzellen an, nicht die gesunden
Ärzte Zeitung online, 29.12.2010
Online Article
- Stangl et al:
Targeting membrane heat-shock protein 70 (Hsp70)
Proc Natl Acad Sci U S A. 2010 Dec 27
Abstract + Full Text (pubmed)
- Stangl et al:
In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody
J Cell Mol Med. 2010 Apr 6.
Abstract (pubmed)
- Elsner et al:
The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.
J Cell Mol Med. 2009 Feb 4
Abstract (pubmed)
- Milani et al:
Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report.
J Transl Med. 2009 Jun 23;7:50
Abstract + Full Text (pubmed)
- Gehrmann et al:
Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3
PLoS ONE. 2008 Apr 2;3(4):e1925
Abstract + Full Text (pubmed)
- Gross et al:
An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation
Leuk Res. 2008 Apr;32(4):527-34. Epub 2007 May 31
Abstract (pubmed)
- Multhoff:
Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance
Methods. 2007 Nov;43(3):229-37
Abstract (pubmed)
- Sherman and Multhoff:
Heat shock proteins in cancer
Ann N Y Acad Sci. 2007 Oct;1113:192-201
Abstract (pubmed)
- Pfister et al:
Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis
Cancer. 2007 Aug 15;110(4):926-35
Abstract (pubmed)
- Schmitt et al:
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
J Leukoc Biol. 2007 Jan;81(1):15-27. Epub 2006 Aug 24
Abstract + Full Text (pubmed)
- Steiner et al:
High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis
Leukemia. 2006 Nov;20(11):2076-9. Epub 2006 Sep 21
Abstract (pubmed)
- Stangl et al:
Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells
J Immunol. 2006 May 15;176(10):6270-6
Abstract + Full Text (pubmed)
- Stangl et al:
Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells.
J Immunol. 176(10):6270-6, 2006.
Abstract (pubmed)
- Radons and Multhoff:
Immunostimulatory functions of membrane-bound and exported heat shock protein 70.
Exerc Immunol Rev.; 11:17-33, 2005.
Abstract + Full Text (pubmed)
- Gastpar et al:
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Cancer Res. 65(12):5238-47, 2005.
Abstract (pubmed)
- Bausero et al:
Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.
J Immunol. 175(5):2900-12, 2005.
Abstract (pubmed)
- Gehrmann et al:
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Cell Death Differ. 12(1):38-51, 2005.
Abstract (pubmed)
- Nylandsted et al:
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
J Exp Med. 200(4):425-35, 2004.
Abstract (pubmed)
- Krause et al:
Treatment of cancer patients with autologous ex vivo Hsp70 peptide activated NK cells: a clinical phase I trial.
Clin Cancer Res. 10 (11):3699-707, 2004.
Abstract (pubmed)
- Gehrmann et al:
Differential up-regulation of cytosolic and membrane-bound Hsp70 in tumor cells by anti-inflammatory drugs.
Clin Cancer Res. 10 (10):335464, 2004.
Abstract (pubmed)
- Gastpar et al:
The cell surface-localized Hsp70 epitope TKD induces migration and cytoltyic activity selectively in human NK cells.
J Immunol 172:972-80, 2004.
Abstract (pubmed)
- Kleinjung et al:
Hsp70 membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
Int J Radiat Oncol Biol Phys. 57(3):820-6, 2003.
Abstract (pubmed)
- Gross et al:
Cell surface-bound Hsp70 mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
J Biol Chem. 17:41173-81, 2003.
Abstract (pubmed)
- Gross et al:
Hsp70-reactivity is associated with increased cell surface density of CD94 and CD56.
Cell Stress & Chaperones. 8(4):348-60, 2003.
Abstract (pubmed)
- Farkas et al:
Hsp70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Melanoma Res. 13:147-52, 2003.
Abstract (pubmed)
- Gehrmann et al:
Membrane-bound Hsp70 in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells.
Haematologica. 88:474-6, 2003.
- Gross et al:
Interaction of Hsp70 peptide with NK cells involves the NK receptor CD94.
Biol Chem. 384(2):267-79, 2003.
Abstract (pubmed)
- Moser et al:
Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by Hsp70-peptide-activated, CD94 positive natural killer cells.
Cell Stress Chaperones. 7(4):365-73, 2002.
Abstract (pubmed)
- Multhoff:
Activation of natural killer cells by Hsp70.
Int J Hyperthermia. 18:576-85, 2002.
Abstract (pubmed)
- Multhoff et al:
A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity.
Cell Stress Chaperones. 6(4):337-44, 2001.
Abstract (pubmed)
- Multhoff et al:
Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.
Int J Cancer. 88:791-7, 2000.
Abstract (pubmed)
- Multhoff et al:
Hsp70 stimulates proliferation and cytolytic activity of natural killer cells.
Hematol. 27:1627-36, 1999.
Abstract (pubmed)
- Multhoff et al:
Hsp70 on tumor cells: a recognition structure for natural killer cells.
J Immunol. 58:4341-50, 1997.
Abstract (pubmed)